| Rit | Winnaar |
|---|---|
| Proloog | Francesco Moser (ITA) |
| Rit 1 | Marino Amadori (ITA) |
| Rit 2 | Giuseppe Saronni (ITA) |
| Rit 3 | Giuseppe Saronni (ITA) |
| Rit 4 | Raniero Gradi (ITA) |
| Rit 5 | Roy Schuiten (NED) |
Datum: 1981-03-18 | Afstand: 202.00 km | UCI:
| Pos | Coureur | Nat | Ploeg |
|---|---|---|---|
| 1 | Raniero Gradi | ITA | - |
| 2 | Leo van Vliet | NED | TI - Raleigh - Creda |
| 3 | Guido Van Calster | BEL | - |
| 4 | Josef Fuchs | ZWI | - |
| 5 | Yvon Bertin | FRA | - |
| 6 | Jan Jonkers | NED | - |
| 7 | Wladimiro Panizza | ITA | - |
| 8 | Giovanni Renosto | ITA | - |
| 9 | Bruno Leali | ITA | - |
| 10 | Pierangelo Bincoletto | ITA | - |
| 16 | Rudy Colman | BEL | - |
| 18 | Henk Lubberding | NED | TI - Raleigh - Creda |
| 20 | Johny Broers | NED | - |
| 24 | Benny Schepmans | BEL | - |
| 30 | Roy Schuiten | NED | - |
| DNF | Joop Zoetemelk | NED | TI - Raleigh - Creda |
| DNF | Bernard Hinault | FRA | - |
| DNF | Giuseppe Saronni | ITA | - |
| DNF | Jan Raas | NED | TI - Raleigh - Creda |